The Effect Of Leukocyte Levels On Antibiotic Therapy In Patients With Urinary Tract Infections (UTIs) at Hospitals in Kudus

Annis Rahmawaty; Sekar Kinasih; Yulia  Pratiwi; Rifda Naufa  Lina; Sri  Suwarni; Mohd Nadzri  Mohd Najib

Authors

Annis Rahmawaty Diploma of Pharmacy, Institut Teknologi Kesehatan Cendekia Utama Kudus, Kudus, Indonesia
Sekar Kinasih Diploma of Pharmacy, Institut Teknologi Kesehatan Cendekia Utama Kudus, Kudus, Indonesia
Yulia Pratiwi Diploma of Pharmacy, Institut Teknologi Kesehatan Cendekia Utama Kudus, Kudus, Indonesia
Rifda Naufa Lina Universitas Negeri Semarang, Indonelsia
Sri Suwarni Diploma of Pharmacy, Sekolah Tinggi Ilmu Farmasi Nusaputera, Selmarang, Indonesia
Mohd Nadzri Mohd Najib Faculty of Pharmacy, Universiti Teknologi MARA, Malaysia

Keywords:

antibiotic, cephalosporine, leukocytes, penicillin, urinary tract infections

Abstract

Urinary tract infections (UTIs) are defined as urine contamination caused by microorganisms in the urinary tract. Characterized by symptoms of fever, chills, malaise, and low back pain, often accompanied by frequency, urgency, and urethral pain during urination. The use of antibiotics can reduce the number of leukocytes in patients with UTIs. The purpose of this study was to determine the effect of antibiotics on leukocytes in Patients with UTIs. This study used a descriptive observational (non-experimental) design with a total sampling technique involving 34 patients. Data were analyzed using the non-parametric Wilcoxon test. The results of this study showed that the largest number was in the age range of 56-65 years as many as 9 patients (25.7%), with the same number of male and female genders, namely 17 patients (50%), the results of the distribution of drug use showed the highest frequency of using Cefuroxime antibiotic therapy as many as 18 patients (52.9%), Cefixime as many as 1 patients (2.9%), Ceftriaxone as many as 9 patients (26.5%), Cefotaxime as many as 4 patients (11.8%) and Ampicillin therapy as many as 2 patients (5.9%). The results of the Wilcoxon test showed that there was a difference in the number of leukocytes before and after antibiotic therapy was given to patients with Urinary Tract Infection. Significant results with a p-value of 0.000 (p ≤ 0.05), which can be interpreted that there is a significant effect. The conclusion is that there is an effect of antibiotics on leukocytes in Patients with UTIs

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