Evaluation of Antihypertensive Therapy Rationality in Hospitalized Hypertensive Patients with Diabetes Mellitus at South Tangerang City General Hospital

Suny Koswara; . Luciana; Nurwulan Adi Ismaya; Rida Ramadhani; Agung Dewantoro; Cyntia Wulandari

doi:10.33751/jf.v16i1.69

Authors

Suny Koswara Stikes Widya Dharma Husada Tangerang
Luciana Department of Pharmacy, Stikes Widya Dharma Husada Tangerang, Banten, Indonesia
Nurwulan Adi Ismaya Department of Pharmacy, Stikes Widya Dharma Husada Tangerang, Banten, Indonesia
Rida Ramadhani Department of Pharmacy, Stikes Widya Dharma Husada Tangerang, Banten, Indonesia
Agung Dewantoro Department of Pharmacy, Stikes Widya Dharma Husada Tangerang, Banten, Indonesia
Cyntia Wulandari Department of Pharmacy, Universitas Pakuan, Bogor, Indonesia

DOI:

https://doi.org/10.33751/jf.v16i1.69

Keywords:

Antihypertensive, diabetes mellitus, evaluation of drug use, rationality drug, South Tangerang Hospital

Abstract

Hypertension is a chronic condition that frequently coexists with diabetes mellitus and may significantly increase the risk of cardiovascular and renal complications. Evaluating the rational use of antihypertensive drugs is important to ensure appropriate therapy. This study aimed to assess the rationality of antihypertensive drug use in hypertensive patients with diabetes mellitus hospitalized at South Tangerang City General Hospital from October 2024 to March 2025. A descriptive cross-sectional design with retrospective data collection was used based on medical records. Total sampling of 67 medical records met the inclusion and exclusion criteria. The rationality of antihypertensive therapy was evaluated using four parameters: appropriate indication, appropriate patient, appropriate drug selection, and appropriate dosage, based on current clinical guidelines. The results showed that all antihypertensive prescriptions met the criteria for rational drug use across all evaluation parameters, with a rationality rate of 100%. Antihypertensive monotherapy was used in 27 (40.29%) patients while combination therapy was used in 40 (59.71%) patients Calcium channel blockers, especially amlodipine, were the most frequently used agents in monotherapy, while the combination of a calcium channel blocker and an angiotensin receptor blocker, particularly amlodipine and candesartan, was the most common regimen. Drug interactions occurred in 23.8% of patients, with severity classified as moderate (92.6 %), and minor (7.40 %). The most frequent interactions occur between bisoprolol and candesartan. Conclusion: antihypertensive prescribing in this population was rational and support cardiovascular and renal protection in diabetes management ; however drug interactions are still present and need attention to improve therapeutic outcomes.

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