Formulation and Evaluation of Antidementia Tablets Containing Broccolli and Centella asiatica Extracts

Vira Handiana; Erni Rustiani; Rini Ambarwati

Authors

Vira Handiana Fitofarmaka
Erni Rustiani Department of Pharmacy, Universitas Pakuan, Bogor, Indonesia
Rini Ambarwati Department of Pharmacy, Universitas Pakuan, Bogor, Indonesia

Keywords:

antidementia, asiaticosides, dissolution, flavonoids, PVP K-30

Abstract

Broccoli is known to contain various bioactive compounds, particularly flavonoids and glucosinolates, which have potential antioxidant and neuroprotective properties. Meanwhile, gotu kola herb (Centella asiatica) contains flavonoid compounds and asiaticosides that are widely recognized for their role in improving cognitive function and supporting brain health. Based on these benefits, this study was conducted to formulate a combined tablet preparation containing broccoli extract and gotu kola herb extract. This study aims to determine the best tablet formulation by evaluating variations in the concentration of the binder PVP K-30, namely 2%, 3%, 4%, and 5%. The evaluation of tablet quality was carried out through several standard physical tests, including hardness testing, friability (brittleness) testing, and crushing time testing. In addition, this study also aimed to determine the dissolution profile of the tablets and to analyze the active substance profile by measuring the levels of flavonoid compounds and asiaticosides contained in the tablet formulation. Statistical analysis of the results demonstrated that all formulated tablets met the general requirements for good tablet quality. Among the tested formulations, formula 4 containing 5% PVP K-30 was identified as the best formula. This formulation showed tablet hardness values ranging from 5.07 to 8.12 kg, friability of 0.2022%, and crushing time between 05'00" and 09'30". The dissolution test results showed a dissolution rate of 87.2523% ± 0.8994. Furthermore, the flavonoid content in the tablets was found to be 5.53 mg QE/g ± 0.0391, while asiaticoside compounds were not detected in the tablet preparation.

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